The Hollow spirit approached her, but stopped when Isshin appeared, catching her and declaring that he was going to protect her.
When she realized that the creature was too fast for her to accurately aim at, she allowed it to get in close and bite her so that she could shoot it from point-blank range.
After she graduated high school, Masaki moved out of the Ishida household, and Isshin opened a small clinic.
The Hollow spirit approached her, falling down a dark hole catching her and declaring that he was going to protect. Masaki, realizing the danger, went after Ichigo to protect him but was not alone.